| Datum | Thuis | Tijd | Uit |
|---|---|---|---|
| Sat 14 Aug |  Fortuna Sittard |
20:00 |  FC Twente |
| Sun 22 Aug | FC Twente |
12:15 |  Ajax |
| Sat 28 Aug |  SC Cambuur |
18:45 | FC Twente |
| Sat 11 Sep | FC Twente |
16:30 |  FC Utrecht |
| Sun 19 Sep |  Vitesse |
14:30 | FC Twente |
| Thu 23 Sep | FC Twente |
21:00 |  AZ Alkmaar |
| Sun 26 Sep |  SC Heerenveen |
14:30 | FC Twente |
| Fri 1 Oct |  FC Groningen |
20:00 | FC Twente |
| Sun 17 Oct | FC Twente |
16:45 |  Willem II |
| Sat 23 Oct | FC Twente |
20:00 |  NEC |
| Sat 30 Oct |  PSV |
21:00 | FC Twente |
| Fri 5 Nov | FC Twente |
20:00 |  Heracles |
| Sat 20 Nov |  Sparta Rotterdam |
18:45 | FC Twente |
| Sun 28 Nov | FC Twente |
14:30 |  Feyenoord |
| Sun 5 Dec |  Go Ahead Eagles |
14:30 | FC Twente |
| Sat 11 Dec | FC Twente |
18:45 |  RKC Waalwijk |
| Sat 18 Dec |  PEC Zwolle |
21:00 | FC Twente |
| Wed 22 Dec | FC Utrecht |
21:00 | FC Twente |
| Sat 15 Jan | FC Twente |
20:00 | SC Heerenveen |
| Sat 22 Jan | Willem II |
21:00 | FC Twente |
| Sat 5 Feb | FC Twente |
21:00 | Vitesse |
| Wed 11 May | FC Twente |
20:00 | FC Groningen |
| Sun 15 May | Feyenoord |
14:30 | FC Twente |
