| Datum | Thuis | Tijd | Uit |
|---|---|---|---|
| zo 30 sep |  FC Twente |
14:30 |  Jong PSV |
| vr 5 okt |  FC Eindhoven |
20:00 | FC Twente |
| zo 14 okt | FC Twente |
16:45 |  MVV Maastricht |
| ma 22 okt |  Jong Utrecht |
20:00 | FC Twente |
| vr 26 okt | FC Twente |
20:00 |  Almere City |
| vr 2 nov | FC Twente |
20:00 |  RKC Waalwijk |
| vr 9 nov |  FC Den Bosch |
20:00 | FC Twente |
| zo 18 nov | FC Twente |
14:30 |  Go Ahead Eagles |
| ma 26 nov |  Jong AZ |
20:00 | FC Twente |
| vr 30 nov | FC Twente |
20:00 |  Jong Ajax |
| vr 7 dec |  FC Volendam |
20:00 | FC Twente |
| vr 14 dec |  SC Cambuur |
20:00 | FC Twente |
| vr 21 dec | FC Twente |
20:00 |  NEC |
| zo 13 jan | MVV Maastricht |
14:30 | FC Twente |
| vr 18 jan | FC Twente |
20:00 | Jong Utrecht |
| vr 25 jan | Almere City |
20:00 | FC Twente |
| vr 1 feb | FC Twente |
20:00 |  Helmond Sport |
| vr 8 feb |  Sparta Rotterdam |
20:00 | FC Twente |
| ma 18 feb | Jong PSV |
20:00 | FC Twente |
| vr 22 feb | FC Twente |
20:00 | FC Eindhoven |
| vr 1 mrt |  Roda JC Kerkrade |
20:00 | FC Twente |
| vr 8 mrt |  FC Oss |
20:00 | FC Twente |
| vr 15 mrt | FC Twente |
20:00 | FC Volendam |
| zo 24 mrt | Go Ahead Eagles |
14:30 | FC Twente |
| vr 29 mrt | FC Twente |
20:00 | FC Den Bosch |
| ma 1 apr | RKC Waalwijk |
20:00 | FC Twente |
| vr 5 apr | FC Twente |
20:00 |  FC Dordrecht |
| vr 12 apr | FC Twente |
20:00 |  Telstar |
| vr 19 apr | Jong Ajax |
20:00 | FC Twente |
| ma 22 apr | FC Twente |
14:30 | Jong AZ |
| vr 26 apr | NEC |
20:00 | FC Twente |
| vr 3 mei | FC Twente |
20:00 | SC Cambuur |
