| Datum | Thuis | Tijd | Uit |
|---|---|---|---|
| za 3 aug |  FC Twente |
20:45 |  PSV |
| za 10 aug |  FC Groningen |
18:30 | FC Twente |
| zo 18 aug | FC Twente |
14:30 |  RKC Waalwijk |
| za 24 aug |  SC Heerenveen |
20:45 | FC Twente |
| zo 1 sep | FC Twente |
12:15 |  FC Utrecht |
| zo 15 sep |  Fortuna Sittard |
16:45 | FC Twente |
| vr 20 sep | FC Twente |
20:00 |  Heracles |
| zo 29 sep |  Feyenoord |
12:15 | FC Twente |
| za 5 okt |  Sparta Rotterdam |
19:45 | FC Twente |
| za 19 okt | FC Twente |
20:45 |  Willem II |
| vr 25 okt | FC Twente |
20:00 |  FC Emmen |
| za 2 nov |  AZ Alkmaar |
20:45 | FC Twente |
| zo 10 nov | FC Twente |
12:15 |  PEC Zwolle |
| zo 24 nov |  VVV-Venlo |
14:30 | FC Twente |
| zo 1 dec | FC Twente |
14:30 |  Ajax |
| za 7 dec |  ADO Den Haag |
18:30 | FC Twente |
| za 14 dec | FC Twente |
20:45 |  Vitesse |
| vr 20 dec | RKC Waalwijk |
20:00 | FC Twente |
| za 18 jan | FC Twente |
18:30 | FC Groningen |
| zo 26 jan | PSV |
16:45 | FC Twente |
| za 1 feb | FC Twente |
19:45 | Sparta Rotterdam |
| zo 9 feb | FC Emmen |
16:45 | FC Twente |
| za 15 feb | FC Twente |
19:45 | AZ Alkmaar |
| zo 23 feb | FC Utrecht |
12:15 | FC Twente |
| za 29 feb | FC Twente |
20:45 | SC Heerenveen |
| za 7 mrt | Vitesse |
20:45 | FC Twente |
| za 14 mrt | Ajax |
19:45 | FC Twente |
| za 21 mrt | FC Twente |
18:30 | ADO Den Haag |
| zo 5 apr | FC Twente |
16:45 | Fortuna Sittard |
| zo 12 apr | PEC Zwolle |
14:30 | FC Twente |
| do 23 apr | FC Twente |
18:30 | VVV-Venlo |
| zo 26 apr | Heracles |
12:15 | FC Twente |
| zo 3 mei | FC Twente |
14:30 | Feyenoord |
| zo 10 mei | Willem II |
14:30 | FC Twente |