| Datum | Thuis | Score | Uit |
|---|---|---|---|
| vr 17 aug |  FC Twente |
2 - 1 |  Sparta Rotterdam |
| vr 24 aug |  Helmond Sport |
2 - 2 | FC Twente |
| vr 31 aug | FC Twente |
3 - 1 |  Roda JC Kerkrade |
| za 8 sep | FC Twente |
1 - 2 |  FC Oss |
| vr 14 sep |  FC Dordrecht |
0 - 2 | FC Twente |
| vr 21 sep |  Telstar |
1 - 3 | FC Twente |
| zo 30 sep | FC Twente |
2 - 1 |  Jong PSV |
| vr 5 okt |  FC Eindhoven |
1 - 1 | FC Twente |
| zo 14 okt | FC Twente |
0 - 1 |  MVV Maastricht |
| ma 22 okt |  Jong Utrecht |
1 - 6 | FC Twente |
| vr 26 okt | FC Twente |
1 - 0 |  Almere City |
| vr 2 nov | FC Twente |
3 - 1 |  RKC Waalwijk |
| vr 9 nov |  FC Den Bosch |
2 - 1 | FC Twente |
| zo 18 nov | FC Twente |
0 - 1 |  Go Ahead Eagles |
| ma 26 nov |  Jong AZ |
1 - 2 | FC Twente |
| vr 30 nov | FC Twente |
2 - 5 |  Jong Ajax |
| vr 7 dec |  FC Volendam |
1 - 2 | FC Twente |
| vr 14 dec |  SC Cambuur |
0 - 1 | FC Twente |
| vr 21 dec | FC Twente |
2 - 0 |  NEC |
| zo 13 jan | MVV Maastricht |
0 - 2 | FC Twente |
| vr 18 jan | FC Twente |
1 - 0 | Jong Utrecht |
| za 26 jan | Almere City |
1 - 3 | FC Twente |
| vr 1 feb | FC Twente |
4 - 1 | Helmond Sport |
| vr 8 feb | Sparta Rotterdam |
0 - 3 | FC Twente |
| ma 18 feb | Jong PSV |
0 - 2 | FC Twente |
| vr 22 feb | FC Twente |
1 - 0 | FC Eindhoven |
| vr 1 mrt | Roda JC Kerkrade |
1 - 1 | FC Twente |
| vr 8 mrt | FC Oss |
0 - 2 | FC Twente |
| vr 15 mrt | FC Twente |
5 - 0 | FC Volendam |
| zo 24 mrt | Go Ahead Eagles |
1 - 2 | FC Twente |
| vr 29 mrt | FC Twente |
1 - 0 | FC Den Bosch |
| ma 1 apr | RKC Waalwijk |
4 - 1 | FC Twente |
| vr 5 apr | FC Twente |
0 - 1 | FC Dordrecht |
| vr 12 apr | FC Twente |
1 - 0 | Telstar |
